GK114 ScienCell 人類小膠質(zhì)細胞極化標記qPCR檢測試劑盒，Human Microglial Polarization Markers qPCR Array Kit

ScienCell 研究實驗室（ScienCell）是一家生物技術公司，其使命是實驗和治療用細胞和細胞相關產(chǎn)品的研究和發(fā)展。 ScienCell為研究界提供各種高質(zhì)量的正常的人類和動物細胞，細胞培養(yǎng)基和試劑，培養(yǎng)基添加因子，細胞來源的RNA，cDNA和蛋白質(zhì)。ScienCell的科學家們以改善生活質(zhì)量，實現(xiàn)細胞的能力，打擊人類退化性疾病為目的研究和開發(fā)各種細胞治療策略。ScienCell總部設在美國加利福尼亞州圣地亞哥，公司成立于1999年。

北京諾博萊德作為ScienCell品牌的特約經(jīng)銷商，為客戶提供，正規(guī)進口，貨期穩(wěn)定，折扣好的服務標準。

GK114 ScienCell人類小膠質(zhì)細胞極化標記qPCR檢測試劑盒，Human Microglial Polarization Markers qPCR Array Kit，產(chǎn)品簡介：

產(chǎn)品品牌： ScienCell

產(chǎn)品貨號：GK114

產(chǎn)品名稱：GK114 ScienCell人類小膠質(zhì)細胞極化標記qPCR檢測試劑盒，Human Microglial Polarization Markers qPCR Array Kit

產(chǎn)品規(guī)格：One 96-well plate, one 20ul reaction per well

GK114 ScienCell人類小膠質(zhì)細胞極化標記qPCR檢測試劑盒，Human Microglial Polarization Markers qPCR Array Kit， 產(chǎn)品說明：

ScienCell的GeneQuery™人小膠質(zhì)細胞偏振標記qPCR陣列試劑盒（GQH-MPM）旨在促進參與小膠質(zhì)細胞極化的40個標記基因的基因表達譜分析，這對調(diào)節(jié)先天免疫功能具有重要意義。當小膠質(zhì)細胞受到刺激時，可以觀察到兩種潛在的表型：促炎M1小膠質(zhì)細胞和抗炎M2小膠質(zhì)細胞。M1表型通過釋放細胞因子和撤銷急性炎癥來保護組織免受入侵病原體的侵害，而M2表型的作用是恢復組織穩(wěn)態(tài)并刺激組織修復。如何根據(jù)其功能對所包含的基因進行分組的簡要示例如下所示：   

M1 表型標記物：TNF、FCGR2A、FCGR2B、FCGR2C、FCGR3A、FCGR3B、CD86、IL1B、NOS2、IL6

M2 表型標記：MRC1、IL4、IL10、TGFB1、IL1R1、SOCS3、ARG1、IL13、SPHK1

激活/靜息標志物：CD80，CLEC5A，HEXB，HLA-DQA1，HLA-DQB1，HLA-DRA，HLA-DRB1，IRF8，ITGAM，MYB，PTGES，RUNX1，TLR3，TLR4

其他小膠質(zhì)細胞標志物：ADGRE1，AIF1，CD40，CD68，EDA，ITGAM，ITGAX，PTPRC

GeneQuery™ qPCR 芯片試劑盒采用 96 孔板格式的 qPCR 就緒，每個孔包含一個引物組，可以特異性識別并有效擴增靶基因的 cDNA。精心設計的引物確保：（i）qPCR分析中的優(yōu)良退火溫度為65°C（含2 mM Mg2+，不含DMSO）;（ii）除非另有說明，否則引物組可識別靶基因的所有已知轉(zhuǎn)錄本變體;（iii）只有一個基因被擴增。每個引物組都已通過qPCR和熔解曲線分析和凝膠電泳進行了驗證。

ScienCell's GeneQuery™ Human Microglial Polarization Markers qPCR Array Kit (GQH-MPM) is designed to facilitate gene expression profiling of 40 marker genes involved in microglial polarization, which has important implications for regulating innate immunological functions. When microglia are stimulated, two potential phenotypes can be observed: pro-inflammatory M1 microglia and anti-inflammatory M2 microglia. The M1 phenotype acts to protect tissues against invading pathogens by releasing cytokines and revoking acute inflammation, while the M2 phenotype acts to restore tissue homeostasis and stimulate tissue repair. Brief examples of how included genes may be grouped according to their functions are shown below:     

·         M1 phenotype marker: TNF, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCGR3B, CD86, IL1B, NOS2, IL6

·         M2 phenotype marker: MRC1, IL4, IL10, TGFB1, IL1R1, SOCS3, ARG1, IL13, SPHK1

·         Activation/resting markers: CD80, CLEC5A, HEXB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IRF8, ITGAM, MYB, PTGES, RUNX1, TLR3, TLR4

·         Additional microglia markers: ADGRE1, AIF1, CD40, CD68, EDA, ITGAM, ITGAX, PTPRC

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis. 

基因查詢™人小膠質(zhì)細胞偏振標志物qPCR陣列板布局*（8 個粗體和斜體控件）

提示：基因選擇可能會根據(jù)新的研究和開發(fā)進行更新

ScienCell基因表達分析產(chǎn)品訂購信息：

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GK005   人上皮細胞生物學qPCR檢測試劑盒，Human Epithelial Cell Biology qPCR Array Kit

GK006   人類神經(jīng)發(fā)育和再生qPCR檢測試劑盒，Human Neural Development and Regeneration qPCR Array Kit

GK007   人類神經(jīng)可塑性qPCR檢測試劑盒，Human Neural Plasticity qPCR Array Kit

GK008   人類神經(jīng)傳遞和膜轉(zhuǎn)運qPCR檢測試劑盒，Human Neural Transmission and Membrane Trafficking qPCR Array Kit

GK009   人類星型膠質(zhì)細胞生物學qPCR檢測試劑盒，Human Astrocyte Cell Biology qPCR Array Kit

GK010   人類黑素細胞發(fā)育和色素沉著qPCR檢測試劑盒，Human Melanocyte Development & Pigmentation qPCR Array Kit

GK011   人類黑素細胞生物學qPCR檢測試劑盒，Human Melanocyte Cell Biology qPCR Array Kit

GK013   人類星型膠質(zhì)細胞轉(zhuǎn)錄因子qPCR檢測試劑盒，Human Astrocyte Transcription Factors qPCR Array Kit

GK017   人血管生成qPCR檢測試劑盒，Human Angiogenesis qPCR Array Kit

GK018   人內(nèi)皮細胞表型異質(zhì)性qPCR檢測試劑盒，Human Endothelial Cell Phenotypic Heterogeneity qPCR Array Kit

GK019   人內(nèi)皮細胞生物學qPCR檢測試劑盒，Human Endothelial Cell Biology qPCR Array Kit

GK020   人B細胞受體信號通路qPCR檢測試劑盒，Human B Cell Receptor Signaling Pathway qPCR Array Kit

GK021   人類T細胞受體信號通路qPCR檢測試劑盒，Human T Cell Receptor Signaling Pathway qPCR Array Kit

GK022   人內(nèi)吞作用qPCR檢測試劑盒，Human Endocytosis qPCR Array Kit

GK023   人皮內(nèi)細胞分化qPCR檢測試劑盒，Human Endothelial Cell Differentiation qPCR Array Kit

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GK025   人類Notch信號通路qPCR檢測試劑盒，uman Notch Signaling Pathway qPCR Array Kit

GK026   人類Wnt信號通路qPCR檢測試劑盒，Human Wnt Signaling Pathway qPCR Array Kit

GK027   人類非經(jīng)典Wnt信號通路qPCR檢測試劑盒，Human Noncanonical Wnt Signaling Pathways qPCR Array Kit

GK028   人類Wnt信號靶基因qPCR檢測試劑盒，Human Wnt Signaling Target Genes qPCR Array Kit

GK029   Human Tie2/Angpt信號qPCR檢測試劑盒，Human Tie2/Angpt Signaling qPCR Array Kit

GK034   人肺纖維化qPCR檢測試劑盒，Human Pulmonary Fibrosis qPCR Array Kit

GK035   人體缺氧反應qPCR檢測試劑盒，Human Hypoxia Response qPCR Array Kit

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